1. Heat butter in a large sauce pan over medium heat; cook & stir onion until slightly tender, about 5 minutes. Add ground beef, Worcestershire sauce, salt, black pepper, garlic powder; cook and stir until beef is browned and crumbly. Remove from heat, drain liquid from beef, and let it sit for 2 minutes.
2. Heat a griddle or flat pan over medium heat spray with cooking oil.
3. Place 1 tortilla on the hot griddle, top with a handful of Colby cheese, ¼ cup of beef mixture, 1 tsp. or ketchup, 1 tsp mustard and 1 tsp of relish. Top with more cheese and an additional tortilla and gently press the tortilla together.
4. Flip quesadilla with a spatula & cook until browned and cheese is melted. Cut quesadilla into 4 pieces. Repeat with remaining tortillas and filling.